Published Studies


Articles That Have Inspired Us

This page provides links to studies discussing the safety of in vivo biopsy.

Risk of tumor cell seeding through biopsy and aspiration cytology

" 94% of breast cancers and 4% liver malignancies showed risk of seeding of tumor cells following biopsy or FNAC. "

A case of mucinous carcinoma of the breast in which needle tract seeding was diagnosed...

" The possibility of tumor seeding must be considered during fine-needle aspiration cytology and biopsy. "

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

" Tumor cell seeding in the needle track during percutaneous needle biopsies has been reported for various types of cancers. The mechanical force of the biopsy both directly displaces the malignant cells and causes bleeding and fluid movement that can further disseminate cells. "

Potential impact of invasive surgical procedures on primary tumor growth and metastasis

" For instance, in early stage tumors, surgical procedures might have no impact on tumor progression because tumor cells still lack the genetic makeup necessary to acquire malignant features when a pro-inflammatory microenvironment is induced "

Breast cancer neoplastic seeding in the setting of image-guided needle biopsies of the breast

" High-grade, triple-negative breast cancers and multiple-insertion, non-coaxial biopsies may be risk factors for NS. [Neoplastic Seeding]"


Can Breast Cancer Biopsy Influence Sentinel Lymph Node Status?

" The macrometastasis rate was 17% (63 of 377) for the 14-gauge and 3% (12 of 377) for the 16- and 18-gauge needles, respectively. "

Cutaneous Metastasis from Breast Tumour Seeding in Percutaneous Needle Biopsy

" Tumour seeding can result in displacement of neoplastic cells that can initiate tumour growth at a separate anatomic site, along the needle tract. Tumour manifestation occurs as a direct result of this procedure, ..."

Seeding of tumour cells following breast biopsy: a literature review

" There is histological evidence of seeding of tumour cells from the primary neoplastic site into adjacent breast tissue following biopsy." 

Core-needle biopsy of breast cancer is associated with a higher rate of distant metastases...

" At 5 to 15 years after diagnosis of the primary tumor, CNB-diagnosed patients had significantly higher rates of distant metastases than FNAB-diagnosed patients." 

Malignant seeding following percutaneous breast biopsy: documentation with comprehensive imaging...

"...  percutaneous breast biopsy can result in malignant seeding, and raises issues regarding informed consent and proper subsequent treatment."

Malignant seeding of the needle track during stereotaxic core needle breast biopsy

" The potential for increased risk of tract seeding of malignancy must be considered."

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